Acute & Chronic Stroke - Potential for Intervention

Grant number: 567156 | Funding period: 2009 - 2012

Completed

Abstract

Stroke is a major cause of death and disability in our community. Most strokes result from a blocked blood vessel in the brain which leads to the almost immediate death of some brain tissue. However surrounding brain tissue is potentially salvageable if blood supply can be restored. This research uses magnetic resonance imaging (MRI) to better demonstrate salvageable brain tissue so that existing treatments to re-open blocked blood vessels can in future be safer and more widely applicable.

Related publications (8)

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Failure of collateral blood flow is associated with infarct growth in ischemic stroke

BCV Campbell, S Christensen, BM Tress, L Churilov, PM Desmond, MW Parsons, P Alan Barber, CR Levi, C Bladin, GA Donnan, SM Davis

2013-08-01

Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion, may impact infarct evolution but ha..

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Advanced imaging improves prediction of hemorrhage after stroke thrombolysis

BCV Campbell, S Christensen, MW Parsons, L Churilov, PM Desmond, PA Barber, KS Butcher, CR Levi, DA De Silva, MG Lansberg, M Mlynash, JM Olivot, M Straka, R Bammer, GW Albers, GA Donnan, SM Davis

2013-04-01

Objective: Very low cerebral blood volume (VLCBV), diffusion, and hypoperfusion lesion volumes have been proposed as predictors of..

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CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke

BCV Campbell, L Weir, PM Desmond, HTH Tu, PJ Hand, B Yan, GA Donnan, MW Parsons, SM Davis

2013-01-01

Background and objective: CT perfusion (CTP) is rapid and accessible for emergency ischaemic stroke diagnosis. The feasibility of ..

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Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke

BCV Campbell, S Christensen, CR Levi, PM Desmond, GA Donnan, SM Davis, MW Parsons

2012-10-01

BACKGROUND AND PURPOSE-: Perfusion imaging has the potential to select patients most likely to respond to thrombolysis. We tested ..

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Assessing response to stroke thrombolysis: Validation of 24-hour multimodal magnetic resonance imaging

BCV Campbell, HTH Tu, S Christensen, PM Desmond, CR Levi, CF Bladin, N Hjort, M Ashkanian, C Sølling, GA Donnan, SM Davis, L Østergaard, MW Parsons

2012-01-01

Background: Imaging is used as a surrogate for clinical outcome in early-phase stroke trials. Assessment of infarct growth earlier..

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The infarct core is well represented by the acute diffusion lesion: Sustained reversal is infrequent

BCV Campbell, A Purushotham, S Christensen, PM Desmond, Y Nagakane, MW Parsons, MG Lansberg, M Mlynash, M Straka, DA De Silva, JM Olivot, R Bammer, GW Albers, GA Donnan, SM Davis

2012-01-01

Diffusion-weighted imaging (DWI) is commonly used to assess irreversibly infarcted tissue but its accuracy is challenged by report..

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Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core

BCV Campbell, S Christensen, CR Levi, PM Desmond, GA Donnan, SM Davis, MW Parsons

2011-12-01

Background and Purpose: CT perfusion (CTP) is widely and rapidly accessible for imaging acute ischemic stroke but has limited vali..

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Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation

BCV Campbell, C Costello, S Christensen, M Ebinger, MW Parsons, PM Desmond, PA Barber, KS Butcher, CR Levi, DA De Silva, MG Lansberg, M Mlynash, JM Olivot, M Straka, R Bammer, GW Albers, GA Donnan, SM Davis

2011-10-01

Background: Fluid-attenuated inversion recovery (FLAIR) hyperintensity within an acute cerebral infarct may reflect delayed onset ..

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